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Development of Biomarkers for Breast Cancer from urine samples using 2-D NOESY NMR

Mary McCourt at Niagara University
Study abstract

The purpose of this exploratory study is to develop a biomarker screen for differentiating healthy breast tissue from diseased breast tissue. Its utility for identifying markers for metastatic disease will also be examined. Urine samples will be used to define biomarkers using NMR and statistical analysis. The general idea of metabolic markers is that differential disease states can be identified using statistical analysis in combination with various experimental techniques. This study will use the Chenomx protocol and samples will be collected from the Army of Women and will be analyzed using 2D NOESY on a 400 MHz Varian NMR.

Study review

This study at Niagara University, in Lewiston, NY, is analyzing urine samples from women with breast cancer and women who have never been diagnosed with any kind of cancer to look for biomarkers that may be a sign of cancerous breast tissue. The researchers will also compare the biomarkers found in the women’s urine to see if they can identify the stage of breast cancer based on the types and levels of the biomarkers. The researchers wanted to enroll at least 200 women who have never been diagnosed with any kind of cancer and at least 1,000 women with breast cancer. The Call to Action for this study was sent to Army of Women members on June 8, 2011, and closed 8 hours later on June 8, 2011, after the Army of Women provided them with 2,075 women who were interested in enrolling in the study.