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Assessment of Cognitive Difficulties in Breast Cancer

Shelli Kesler, PhD, Stanford University
Study abstract

The goals of the proposed research are to 1) define the specific cognitive deficits associated with BC and chemotherapy using comprehensive, ecologically valid neuropsychological assessment, 2) elucidate the neurobiologic states underlying cognitive impairments in women with BC using advanced neuroimaging techniques, 3) identify demographic, medical and genetic factors associated with cognitive outcome in BC and 4) test the efficacy of two innovative treatment methods – one for improving existing cognitive impairments and the other for preventing cognitive impairments. The proposed research will implement highly innovative methods including measurement of hippocampal neural stem cells, using neurofeedback as a preventative treatment method and evaluating a combination of genetic variants believed to influence cognitive outcome.

Study review

This study at Stanford University in Palo Alto, CA, is using cognitive tests and MRI scans to learn more about how breast cancer and its treatments can affect the brain and cognitive functioning. The study will compare women who have never had breast cancer to women with breast cancer. The researchers wanted to enroll 100 healthy women from the Army of Women. The Call to Action for this study was sent to Army of Women members on June 26, 2013. The researchers were able to close enrollment one day later, on June 27, 2013, after the Army of Women provided them with 293 women who were interested in enrolling in the study.

Resulting Publications: